404: Page not Found

I am creating my website, as i am customizing it, before i could click menu or create menu, it displays ‘404: Page not found, the page could not be display’. What is responsible for this? please help.
Thank you very much.

Where do you see this sorry?

Look at the screen shot. I am to customize it when this happens.

Try settings > permalinks > default/plain

I have checked the permalink settings, I can not find anything wrong.
See the screen capture.

Thanks

Hit plain see what happens?